Clinical and epidemiological profile of Inflammatory Bowel Disease in a reference center in gastroenterology in western Paraná

Authors

  • Denise Caroline Barros da Silva Centro Universitário da Fundação Assis Gurgacz
  • Tomaz Massayuki Tanaka Centro Universitário da Fundação Assis Gurgacz; Universidade Estadual do Oeste do Paraná

DOI:

https://doi.org/10.52076/eacad-v4i2.486

Keywords:

Inflammatory Bowel Disease; Crohn's disease; Ulcerative Colitis; Epidemiology.

Abstract

Inflammatory Bowel Disease, represented by Ulcerative Colitis and Crohn's Disease, have shown, in recent decades, an increase in their rates globally. In Brazil, there are still few epidemiological studies about these diseases, and, as a result, it is important to outline the epidemiological profile of these patients, in order to contribute to the national scientific literature. Objective: The clinical and epidemiological profile of patients affected by IBD from 2015 to 2019 was evaluated, obtaining the data: age, family history, clinical picture, diagnosis, most affected intestinal segment, extraintestinal manifestations and treatment. These variables were compared with each other and with national data to establish a local overview of the disease in order to guide the medical community. Methods: The study included patients undergoing treatment at a private medical center in Cascavel-PR with a confirmed diagnosis of IBD. Data were collected secondarily through a data collection system, SisClínica. Results: Of the 50 patients, 68% were female and 32% were male. The most affected ethnicity was white. The most affected age group was between 20 and 59 years, the most common diagnosis was UC in 86% of patients and 14% with Crohn's disease. Their main symptoms were bloody diarrhea and abdominal pain; regarding treatment, 75.75% used systemic salicylates; 6% of patients underwent surgical treatment during treatment. Conclusion: the present study showed that IBD patients in Cascavel-PR were consistent with the national findings.

References

BOHL, Jaime L.; SOBBA, Kathryn. Indications and Options for Surgery in Ulcerative Colitis. Surg Clin N Am, [s. l.], v. 95, p. 1211–1232, 2015. https://doi.org/10.1016/j.suc.2015.07.003.

BURGMANN, Twila. The Manitoba Inflammatory Bowel Disease Cohort Study: Prolonged Symptoms Before Diagnosis—How Much Is Irritable Bowel Syndrome?. Clinical Gastroenterology and Hepatology, [s. l.], v. 2006, n. 5, ed. 4, 7 maio 2023. https://doi.org/10.1016/j.cgh.2006.03.003.

DALL’OGLIO, Vincent Marin; BALBINOT, Rafael Sartori; MUSCOPE, Ana Laura Facco; CASTEL, Mateus Dal; SOUZA, Thianan Ricardo; MACEDO, Renan Souza de; OLIVEIRA, Thanize Barbosa de; BALBINOT, Raul Angelo; BALBINOT, Silvana Sartori; BRAMBILLA, Eduardo; SOLDERA, Jonathan. Epidemiological profile of inflammatory bowel disease in Caxias do Sul, Brazil: a cross-sectional study. Säo Paulo med. j, [s. l.], v. 138, ed. 6, p. 530-536, 2020. https://doi.org/10.1590/1516-3180.2020.0179.R2.10092020.

ELIA, Paula Peruzzi; FOGAÇA, Homero Soares; BARROS, Rodrigo G. G. Rego; ZALTMAN, Cyrla; ELIA, Celeste Siqueira C. Análise descritiva dos perfis social, clínico, laboratorial e antropométrico de pacientes com doenças inflamatórias intestinais, internados no Hospital Universitário Clementino Fraga Filho, Rio de Janeiro. Arq Gastroenterol, [s. l.], v. 44, ed. 4, p. 332-339, 2007. https://www.scielo.br/j/ag/a/LBpftgjSDNY4FHRyRNW9cNH/?lang=pt.

FARINA, Bruna. Perfil epidemiológico de pacientes com doença inflamatória intestinal. 2019. 53 f. Trabalho de conclusão de curso (Bacharelado em Medicina) - Universidade Federal da Fronteira Sul, [S. l.], 2019. https://rd.uffs.edu.br/handle/prefix/3549.

GASPARINI, Rodrigo Galhardi; SASSAKI, Ligia Yukie; SAAD-HOSSNE, Rogerio. Inflammatory bowel disease epidemiology in São Paulo State, Brazil. Clinical and Experimental Gastroenterology, [s. l.], v. 11, p. 423–429, 30 out. 2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214600/.

HOVDE, Øistein; MOUM, Bjørn A. Epidemiology and clinical course of Crohn ‘s disease: results from observational studies. World Journal of Gastroenterology, [s. l.], v. 18, ed. 15, p. 1723-1731, 21 abr. 2012. DOI doi: 10.3748/wjg.v18.i15.1723. https://www.wjgnet.com/1007-9327/full/v18/i15/1723.htm.

JOHNSON, Amanda M.; JR, Edward V. Loftus. Obesity in inflammatory bowel disease: A review of its role in the pathogenesis, natural history, and treatment of IBD. Saudi Journal of Gastroenterology, [s. l.], v. 27, ed. 4, p. 183–190, 2021. DOI 10.4103/sjg.sjg_30_21. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8448008/.

KHASAWNEH, Mais; SPENCE, Andrew D; ADDLEY, Jennifer; ALLEN, Patrick B. The role of smoking and alcohol behaviour in the management of inflammatory bowel disease. Best Practice & Research Clinical Gastroenterology, [s. l.], v. 31, ed. 5, p. 553-559, 2017. https://www.sciencedirect.com/science/article/abs/pii/S1521691817301166?via%3Dihub.

KLEINUBING - JÚNIOR, Harry; PINHO, Mauro de S. L.; FERREIRA, Luis Carlos; BACHTOLD, Guilherme Augusto; MERKI, Amanda. Outpatients profile with inflammatory bowel disease. ABCD. Arquivos Brasileiros de Cirurgia Digestiva, [s. l.], v. 24, ed. 3, p. 200-203, setembro 2011. DOI https://doi.org/10.1590/S0102-67202011000300004. https://www.scielo.br/j/abcd/a/9fcn7WSgF4qYnMYV88BCqwb/?lang=en .

LAKATOS, Laszlo; PANDUR, Tunde; DAVID, Gyula; BALOGH, Zsuzsanna; KURONYA, Pal; TOLLAS, Arpad; LAKATOS, Peter Laszlo. Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype: Results of a 25-year follow-up study. World Journal Gastroenterology, [s. l.], v. 9, ed. 10, p. 2300-2307, 2003. DOI 10.3748/wjg.v9.i10.2300. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656482/.

MOTA, E. S. et al.. Manifestações extra-intestinais em doença de Crohn e retocolite ulcerativa: prevalência e correlação com o diagnóstico, extensão, atividade, tempo de evolução da doença. Revista Brasileira de Coloproctologia, v. 27, n. 4, p. 349–363, out. 2007. https://www.scielo.br/j/rbc/a/qXBdGsvLtdDTn4zRQT9jfcq/.

NG, Siew C; SHI, Hai Yun; HAMIDI, Nima; UNDERWOOD, Fox E; TANG, Whitney; BENCHIMOL, Eric I; PANACCIONE, Remo; GHOSH, Subrata; WU, Justin C Y; CHAN, Francis K L; SUNG, Joseph J Y; KAPLAN, Gilaad G. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. The Lancet, [s. l.], v. 390, ed. 10114, p. 2769-2778, 2017. https://pubmed.ncbi.nlm.nih.gov/29050646/ .

ORDÁS, Ingrid et al. Ulcerative colitis. The Lancet, [s. l.], v. 380, ed. 9853, p. 1606-1619, nov 2012. Disponível em: https://doi.org/10.1016/S0140-6736(12)60150-0.

PARENTE, José Miguel Luz et al. Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil. World Journal Gastroenterology, [s. l.], v. 21, ed. 4, p. 1197-1206, 28 jan. 2015. DOI: 10.3748/wjg.v21.i4.1197. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306164/.

PEREIRA, A. S. et al. Metodologia da pesquisa científica. [free e-book]. Santa Maria/RS. Ed. UAB/NTE/UFSM, 2018.

RADHAKRISHNA, Rao. Endotoxemia and Gut Barrier Dysfunction in Alcoholic Liver Disease. Hepatology, [s. l.], v. 50, ed. 2, p. 638–644, aug 2009. DOI 10.1002/hep.23009. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209509/.

ROGLER, Gerhard Rogler; SINGH, Abha; KAVANAUGH, Arthur; RUBIN, David T. Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management. American Gastroenterological Association, [s. l.], v. 161, ed. 4, p. 1118-1132, 3 ago. 2021. https://doi.org/10.1053/j.gastro.2021.07.042.

SAIRENJI, Tomoko; COLLINS, Kimberly L.; EVANS, David V. An Update on Inflammatory Bowel Disease. Primary Care: Clinics in Office Practice, [s. l.], v. 44, ed. 4, p. 673-692, 2017. https://www.sciencedirect.com/science/article/abs/pii/S0095454317301045?via%3Dihub.

ROSA, Juliana Rodrigues da; JÚNIOR, Josué Ferreira da Silva; ROSA, Maria Inês da. Perfil epidemiológico de portadores de doença inflamatória intestinal. Arquivos Catarinenses de Medicina , [s. l.], v. 43, ed. 2, p. 53-58, 2014. http://www.acm.org.br/revista/pdf/artigos/1287.pdf.

SILVA, Alice Freitas da; SCHIEFERDECKER, Maria Eliana Madalozzo; ROCCO, Cláudia Seely; AMARANTE, Heda Maria Barska dos Santos. Relationship between nutritional status and inflammatory activity in patients with inflammatory bowel disease. ABCD Arq Bras Cir Dig, [s. l.], v. 23, ed. 3, p. 154-158, 2010. https://www.scielo.br/j/abcd/a/prG7YCkLWdXq7qRZmQfvtsC/abstract/?lang=pt.

SOUZA, Mardem Machado de; BELASCO, Angélica Gonçalves Silva; NASCIMENTO, José Eduardo de Aguilar. The Epidemiological Profile of Patients with Inflammatory Bowel Disease in the State of Mato Grosso. Revista Brasileira de Coloproctologia, [s. l.], v. 28, ed. 3, p. 324-328, 2008. DOI https://doi.org/10.1590/S0101-98802008000300009. https://www.scielo.br/j/rbc/a/3RyDkHyczzZRBcTp9kKRbrh/?lang=pt

TORRES, Joana; MEHANDRU, Saurabh; COLOMBE, Jean-Frédéric; PEYRIN-BIROULET, Laurent. Crohn’s disease. The Lancet, [s. l.], v. 389, ed. 10080, p. 1741-1755, apr 2017. DOI https://doi.org/10.1016/S0140-6736(16)31711-1. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)31711-1/fulltext

TRONCON, Luiz Ernesto de A. Trends in the occurrence (1980-1999) and clinical features of Crohn‘s disease and ulcerative colitis in a university hospital in southeastern Brazil. Arquivos de Gastroenterologia, [s. l.], v. 39, ed. 2, p. 98-105, abril 2002. DOI https://doi.org/10.1590/S0004-28032002000200006. https://pubmed.ncbi.nlm.nih.gov/12612713/ .

Published

24/06/2023

How to Cite

Silva, D. C. B. da, & Tanaka, T. M. . (2023). Clinical and epidemiological profile of Inflammatory Bowel Disease in a reference center in gastroenterology in western Paraná. E-Acadêmica, 4(2), e2442486. https://doi.org/10.52076/eacad-v4i2.486

Issue

Section

Health and Biological Sciences