Medication-induced osteonecrosis of the maxilla, potentiated by fungical infection: Case report
DOI:
https://doi.org/10.52076/eacad-v4i1.404Keywords:
Bisphosphonate; Osteonecrosis; Actinomicosis.Abstract
Osteonecrosis of the jaws induced using bisphosphonates refers to a condition characterized by the exposure of necrotic bone, usually in the face region and commonly originating from trauma. Osteonecrosis induced by bisphosphonates has its highest prevalence in the mandible and may be initially manifested by ulcerations in the oral mucosa, which expose the underlying bone due to its poor vascularization and the use of bisphosphonates. Bisphosphonates are indicated for the treatment of several comorbidities, such as malignant tumors, bone metastases, osteoporosis. Actinomycosis is rarely a pathological concern due to the low virulence of the organism, but it can manifest itself when associated with other pathologies such as osteonecrosis. The clinical case presents a patient who made prolonged use of bisphosphonates associated with low-intensity trauma evolving to maxillary osteonecrosis potentiated by actnomyses. This article aims to demonstrate the connection between actinomycosis and chronic osteonecrosis and the importance of correct diagnosis for correct treatment.
References
American Association of Oral and Maxillofacial Surgeons (AAOMS) (2016). Medication-Related Osteonecrosis of the Jaw – 2016 update. E.U.A.
Agarwal, P., Chug, A., Kumar, S., & Jain, K. (2019, May). Palatal actinomycosis osteomyelitis–Complication of impacted tooth in a diabetic. Special Care in Dentistry. 39(3), 319–323.
Crossman, T., & Herold, J. (2009, Feb). Actinomycosis of the maxilla - A case report of a rare oral infection presenting in general dental practice. British Dental Journal. 206(4), 201–202.
Dimitrakopoulos, C., & Magopoulos, D. K. (2006) Bisphosphonate-induced avascular osteonecrosis of the jaws: a clinical report of 11 cases. International Journal of Oral & Maxillofacial Surgery. 35(1), 588-593.
Gannepalli, A., Ayinampudi, B. K., Baghirath, P. V., & Reddy, G. V. (2015). Actinomycotic Osteomyelitis of Maxilla Presenting as Oroantral Fistula: A Rare Case Report. Case Reports in Dentistry. (1)01-05.
Haggerty, C. J., & Tender, G. C. (2012). Actinomycotic brain abscess and subdural empyema of odontogenic origin: Case report and review of the literature. Journal of Oral and Maxillofacial Surgery. 70(3).
Hirshberg, A., Tsesis, I., Metzger, Z., & Kaplan, I. (2003). Periapical actinomycosis: A clinicopathologic study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 95(5), 614–620.
Infante-Cossio, P., Lopez-Martin, J. C., Gonzalez-Cardero, E., Martinez-De-Fuentes, R., & Casas-Fernandez-Tejerina, A. (2012, Jul). Osteonecrosis of the maxilla associated with cancer chemotherapy in patients wearing dentures. Journal of Oral and Maxillofacial Surgery. 70(7), 1587–1592.
Marx, R. E. (2007). Oral & intravenous bisphosphonate-induced osteonecrosis of the jaws: History, etiology, prevention, and treatment. Quintessence Publising Co. 1. p.05–150.
McCann, A., Alvi, S. A., Newman, J., Kakarala, K., Staecker, H., & Chiu A. (2019, Feb). Atypical Form of Cervicofacial Actinomycosis Involving the Skull Base and Temporal Bone. Annals of Otology, Rhinology and Laryngology. 128(2). 152–156.
Meethal AC, Pattamparambath M, Balan A, Kumar NR, & Sathyabhama S. (2016) Actinomycotic osteomyelitis of the maxilla - A delusive presentation. Journal of Clinical and Diagnostic Research., 10(7).
Migliorati, C. A, Schubert, M. M., Peterson, D. E., & Seneda, L. M. (2005) Bisphosphonate-Associatade Osteonecrosis of Madibular and Maxillary Bone. American Cancer Society. 104(1), 83-93.
Motta, A. C. F., Macedo, L. D., Santos, G. G., Guerreiro, C. T., Ferrari, T., Oliveira, T. F. L., Oliveira-Santos, C., Xavier, S. P., & Iannetta, O. (2015). Quantitative Ultrasound at the hand Phalanges in patients with bisphosphonate-related osteonecrosis of the jaws. Brazillian Oral Research. 29(1), 01-09.
Ponte, F. S., Catalfamo, L., Micali, G., Runci, M., Cutroneo, G., Vermiglio, G., Centofanti, A., & Rizzo, G. (2016). Effect of Bisphosphonates on the Mandibular Bone and Gingival Epithelium of Rats Witout Tooth Extraction. Experimental and Therapeutic Medicine. 11(1). 1678-1684.
Ruggiero, S. L. (2015). Diagnosis and Staging of Medication-Related Osteonecrosis of the Jaw. Oral Maxillofacial Surgery Clinic. 62, 01-09.
Ruggiero, S. L., Gralow, J., Marx, R. E., Hoff, A. O., Schubert, M. M., Huryn, J. M., Toth, B., Damato, K., & Valero, V. (2006). Practical Guidelines for the Prevention, Diagnosis, and Treatment of Osteonecrosis of the Jaw in Patients with Cancer. Journal of Oncology Practice. 2(1), 07-14.
Senturk, M. F., Cimen, E., Öncul, A. M. T., & Cambazoglu, M. (2016). Oncologists Awareness About Bisphosphonate Related Osteonecrosis of the Jaws. Journal of Pakistan Medical Association. 66(7).
Sezer, B., Akdeniz, B. G., Günbay, S., Hilmioğlu-Polat, S., & Başdemir, G. (2017) Actinomycosis osteomyelitis of the jaws: Report of four cases and a review of the literature. Journal of Dental Sciences. 12(3), 301–307.
Steven-Fergus, H., & Savord, E. G. (1980). Actinomycosis involving a periapical cyst in the anterior maxilla Report of a case. Oral surgery, Oral medicine, Oral pathology. 49(5). p.390-393.
Suzuki, K., Kurihara, J., Kim, M., Yanagisawa, S., Ogawa, M., & Makiguchi T. (2021). Image screening for maxillo-mandibular actinomycosis with CT, 18F-FDG-PET/CT, and 18F-α-methyl tyrosine PET/CT. Oral Radiology. 37(1), 46–54.
Vescovi, P., Merigo, E., Manfredi, M., Meleti, M., Fornaini, C., Bonanini, M., Rocca, J. P., & Nammour, S. (2008). Nd: YAG Laser Biostimulation in the Treatment of Bisphophonate-Associated Osteonecrosis of the Jaws: Clinical Experience in 28 Cases. Photomedicine and Laser Surgery. 26(1), 37-46.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Gabriel Cunha Collini; Bianca de Fatima Borim Pulino; Guilherme Cunha Collini; Raphael Capelli Guerra
This work is licensed under a Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
