Cutaneous manifestations in patients with Covid-19
DOI:
https://doi.org/10.52076/eacad-v3i3.362Keywords:
Skin and connective tissue diseases; Coronavirus; Review.Abstract
The disease COVID-19 is caused by a family of viruses called coronavirus. The most frequent clinical manifestations of the disease include fatigue, fever, headache, myalgia, cough and diarrhea. In addition, some patients develop Acute Respiratory Distress Syndrome. Infection-related skin lesions are also described. Therefore, it is a disease that causes manifestations in multiple organs and systems, including the skin. The cutaneous manifestations of COVID-19 are not yet known in their entirety, but the number of case reports on tegumentary involvement in the disease is increasing. The objective of this research was to carry out a systematic review of the dermatological manifestations caused by the COVID-19 infection. Systematic literature review in MEDLINE/PUBMED, Latin American and Caribbean Health Sciences Literature (LILACS) and Scientific Electronic Library Online (SciELO) was performed. Considering the inclusion and exclusion criteria, a systematic review of the dermatological manifestations caused by the COVID-19 infection was identified. According to the selected studies, there was significance in the results regarding 23 articles indexed in PUBMED and no articles in LILACS or Scielo. There is a high prevalence of dermatological lesions in patients with COVID-19. Furthermore, the changes observed are extremely important, as findings such as rash, urticaria and erythematous lesions may play a role in the early diagnosis of asymptomatic patients, even if their etiology is uncertain.
References
Atkins, D., Best, D., Briss, P.A., et al. (2004) Grading quality of evidence and strength of recommendations. BMJ (Clinical Research ed). 328(7454): 1490.
Brasil. (2020). COVID-19: ponto a ponto sobre o novo coronavírus. Brasília, 2020. https://www.fiocruzbrasilia.fiocruz.br/covid-19-ponto-a-ponto-do-novo-coronavirus/
Brasil. (2021). O que é COVID-19. Brasília, 2021. https://coronavirus.saude.gov.br/sobre-a-doenca
Brasil (2021). A pandemia de Covid-19: Interseções e desafios para a história da saúde e do tempo presente. Brasília, 2021. https://portal.fiocruz.br/sites/portal.fiocruz.br/files/documentos/a-pandemia-de-covid-19_intersecoes-e-desafios-para-a-historia-da-saude-e-do-tempo-presente.pdf Acesso: 19 de Março de 2021.
De Souza, R.J., Mente, A., Maroleanu, A., et al. (2015). Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. BMJ (Clinical research ed).351 :h3978.
De Wit, E., Van Doremalen, N., Falzarano, D., et al. (2016). SARS and MERS: Recent insights into emerging coronaviruses. Nat Rev Microbiol. 14 (8): 523-34.
Drago, F., Ciccarese, G., Rebora, A., et al. (2020). SARS-CoV-2 infection: the same virus can cause different cutaneous manifestations. Br J Dermatol. 183(4):788. 10.1111/bjd.19311.
Galli, E., Cipriani, F., Ricci, G., et al. (2020). Cutaneous manifestation during COVID-19 pandemic. Pediatr Allergy Immunol..31 Suppl 26(Suppl 26):89-91. 10.1111/pai.13384.
Gisondi, P., Piaserico, S., Bordin, C., Alaibac, M.,et al. (2020). Cutaneous manifestations of SARS-CoV-2 infection: a clinical update. J Eur Acad Dermatol Venereol.34(11):2499-2504. 10.1111/jdv.16774.
Guelimi, R., Salle, R., Dousset, L., Assier, H., et al. (2021). Non-acral skin manifestations during the COVID-19 epidemic: COVIDSKIN study by the French Society of Dermatology. J Eur Acad Dermatol Venereol. 35(9):e539-e541. 10.1111/jdv.17322.
Jia, J.L., Kamceva, M., Rao, S.A., et al. (2020). Cutaneous manifestations of COVID-19: A preliminary review. J Am Acad Dermatol. 83(2):687-690. 10.1016/j.jaad.2020.05.059.
Jouret, G., Damsin, T., Vanhakendover, L., Bailleux, S,, et al. (2020). Dermatological manifestations of COVID-19. Rev Med Liege. Sup;75(S1):115-118.
Klejtman, T. Skin and COVID-19. (2020). J Med Vasc. 45(4): 175–176.,19.
Li, H., Zhao, Y., Zhou, L., et al. (2020). Cutaneous, skin histopathological manifestations and relationship to COVID-19 infection patients. Dermatol Ther. 33(6):e14157. 10.1111/dth.14157. Epub 2020 Sep 7.
Méndez Maestro, I., Peña Merino, L., Udondo González Del Tánago., et al. (2020). Skin manifestations in patients hospitalized with confirmed COVID-19 disease: a cross-sectional study in a tertiary hospital. Int J Dermatol. 59(11):1353-1357. 10.1111/ijd.15180. Epub 2020 Sep 24.
Miot, H.A., Ianhez, M., Müller Ramos, P. (2021). Self-reported cutaneous manifestations in 1429 Brazilian COVID-19-infected patients. J Eur Acad Dermatol Venereol. 35(3):e172-e173. 10.1111/jdv.17024. Epub 2020 Nov 24.
Mirza, F.N., Malik, A.A., Omer, S.B., et al. (2021). Dermatologic manifestations of COVID-19: a comprehensive systematic review. Int J Dermatol. 60(4):418-450. 10.1111/ijd.15168.
Molaee, H., Allahyari, F., Emadi, S.N., (2021). Cutaneous manifestations related to the COVID-19 pandemic: a review article. Cutan Ocul Toxicol. 40(2):168-174. 10.1080/15569527.2021.1919138.
Naderi-Azad, S., Vender, R.. (2021) Lessons From the First Wave of the Pandemic: Skin Features of COVID-19 Can Be Divided Into Inflammatory and Vascular Patterns. J Cutan Med Surg. 25(2):169-176. 10.1177/1203475420972343.
Oliveira, C.B., Maher, C.G., Franco, M.R., et al. (2020). Co-occurrence of Chronic Musculoskeletal Pain and Cardiovascular Diseases: A Systematic Review with Meta-analysis. Pain medicine (Malden, Mass).21(6): 1106-21
Patrick, M.T., Zhang, H., Wasikowski, R, et al. (2021) Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies. J Allergy Clin Immunol. 147(3):857-869.e7. 10.1016/j.jaci.2021.01.006.
Pinheiro, L.S.P., Ocariano, J.M., Madaleno, F.O., et al. (2020) Prevalence and incidence of injuries in para athletes: a systematic review with meta-analysis and GRADE recommendations. British Journal of Sports Medicine. bjsports-2020- 102823.
Rajan, M.B., Kumar-M, P., Bhardwaj, A. (2020) The trend of cutaneous lesions during COVID-19 pandemic: lessons from a meta-analysis and systematic review. Int J Dermatol. 59(11):1358-1370. 10.1111/ijd.15154.
Rekhtman, S., Tannenbaum, R., Strunk, A., Birabaharan, M., et al. (2021). Eruptions and related clinical course among 296 hospitalized adults with confirmed COVID-19. J Am Acad Dermatol. 84(4):946-952. 10.1016/j.jaad.2020.12.046.
Rerknimitr, P., Theerawattanawit, C., Lertpichitkul, P., et al. (2020). Skin manifestations in COVID-19: The tropics experience. J Dermatol. 47(12):e444-e446. 10.1111/1346-8138.15567.
Rrapi, R., Chand, S., Lo, J.A., et al. (2021). The significance of pressure injuries and purpura in COVID-19 patients hospitalized at a large urban academic medical center: A retrospective cohort study. J Am Acad Dermatol. 85(2):462-464. 10.1016/j.jaad.2021.03.051.
Sameni, F., Hajikhani, B., Yaslianifard, S., et al. (2020) COVID-19 and Skin Manifestations: An Overview of Case Reports/Case Series and Meta-Analysis of Prevalence Studies. Front Med (Lausanne). 7:573188. 10.3389/fmed.2020.573188. eCollection 2020.
Seirafianpour, F., Sodagar, S., Pour Mohammad, A., et al. (2020). Cutaneous manifestations and considerations in COVID-19 pandemic: A systematic review. Dermatol Ther. 33(6):e13986. 10.1111/dth.13986.
Stroup, D.F., Berlin, J.A., Morton, S.C., et al. (2020).Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. Jama. 283(15):2008-12.
Taylor, J.B., Goode, A.P., George, S.Z., Cook, C.E. (2014). Incidence and risk factors for first-time incident low back pain: a systematic review and meta-analysis. The spine journal : official journal of the North American Spine Society. 14(10):2299-319.
Tomsitz, D., Biedermann, T., Brockow, K. (2021). Skin manifestations reported in association with COVID-19 infection. J Dtsch Dermatol Ges. 19(4):530-534. 10.1111/ddg.14353.
Tsai, P.H., Lai, W.Y., Lin, Y.Y., Luo, Y.H., et al. (2021) Clinical manifestation and disease progression in COVID-19 infection. J Chin Med Assoc. 84(1):3-8. 10.1097/JCMA.0000000000000463.
Visconti, A., Bataille, V., Rossi, N., Kluk, J., et al. (2021). Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection. Br J Dermatol. 184(5):880-887. 10.1111/bjd.19807.
Wollina, U., Karadağ, A.S., Rowland-Payne, C., et al. (2020). Cutaneous signs in COVID-19 patients: A review. Dermatol Ther. 2020 Sep;33(5):e13549. 10.1111/dth.13549.
World Health Organization (WHO). WHO Director-General's opening remarks at the media briefing on COVID-19. https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020.
Yuce, M., Filiztekin, E., Ozkaya, K.G. (2020). COVID-19 diagnosis - A review of current methods. Elsevier Public Helth Emergency Collection, Biosensors and Bioelectronics 172 (2021) 112752. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584564/pdf/main.pdf
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Copyright (c) 2022 João Victor Costa Cezar de Andrade; Letícia Ferreira Gasques; Marilda Aparecida Milanez Morgado de Abreu; Ana Cláudia Cavalcante Espósito
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