Nutritional approach to Alzheimer´s disease: a literature review

Authors

  • Luísa Simões Almeida Centro de Ensino Unificado de Brasília
  • Amanda Pupe Zupi Centro de Ensino Unificado de Brasília

DOI:

https://doi.org/10.52076/eacad-v3i2.134

Keywords:

Alzheimer's disease; Neurodegenerative disease; Nutrients; Food.

Abstract

Introduction: Alzheimer's disease (AD) is characterized as a neurodegenerative disease, and there is still no clinical cure for this disease, which progresses over time. However, many studies report and prove that through food, we can prevent and/or alleviate the symptoms of AD. Objective: To elucidate the nutrients and dietary patterns that can help in the prevention and treatment of Alzheimer's disease. Methodology: This study consisted of a narrative review of the literature and 30 scientific articles were selected for this review. Among the inclusion criteria, articles from the years 2014 to 2021, in the public domain, original research from scientific journals, monographs, thesis, dissertation and articles were selected. Exclusion criteria were articles not consistent with the topic, studies carried out on animals, research carried out with other neurodegenerative diseases and studies carried out with people under 30 years of age.

Results: Associated with the delay of cognitive decline, nutrients from omega 3, B vitamins, vitamins C, flavonoids and polyphenols showed positive results in relation to this disease. Conclusion: The inclusion of nutrients, physical activities and exercises for cognitive function are relevant to contribute to the reduction of the incidence of Alzheimer's Disease.

References

Abate, G., Marziano, M., Rungratanawanich, W., Memo, M., & Uberti, D. (2017, January 12). Nutrition and AGE-ing: Focusing on Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. https://www.hindawi.com/journals/omcl/2017/7039816/

Balbino, C. de S. (2021). A influência da alimentação no tratamento da doença de alzheimer / The influence of food in the treatment of alzheimer’s disease. Brazilian Journal of Health Review, 4(3), 10279–10293. https://doi.org/10.34119/bjhrv4n3-055

Barnard, N. D., Bush, A. I., Ceccarelli, A., Cooper, J., de Jager, C. A., Erickson, K. I., Fraser, G., Kesler, S., Levin, S. M., Lucey, B., Morris, M. C., & Squitti, R. (2014). Dietary and lifestyle guidelines for the prevention of Alzheimer’s disease. Neurobiology of Aging, 35, S74–S78. https://doi.org/10.1016/j.neurobiolaging.2014.03.033

Bhatti, G. K., Reddy, A. P., Reddy, P. H., & Bhatti, J. S. (2020). Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer’s Disease. Frontiers in Aging Neuroscience, 11. https://doi.org/10.3389/fnagi.2019.00369

De Cássia, B., Bigueti1, P., Zeitum De Lellis, J., Chioda, J., & Dias, R. (2018). Nutrientes essenciais na prevenção da doença de Alzheimer Essential nutrients in the prevention of Alzheimer’s disease. Revista Ciências Nutricionais Online, 2, 18–25. https://unifafibe.com.br/revistasonline/arquivos/cienciasnutricionaisonline/sumario/62/13042018180525.pdf

van den Brink, A. C., Brouwer-Brolsma, E. M., Berendsen, A. A. M., & van de Rest, O. (2019). The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer’s Disease—A Review. Advances in Nutrition, 10(6). https://doi.org/10.1093/advances/nmz054

Alves Carnauba, R. (2019). Rev Bras Nutr Func, 45(80). https://doi.org/10.32809/2176-4522.45.80.01

Clark, D. O., Xu, H., Moser, L., Adeoye, P., Lin, A. W., Tangney, C. C., Risacher, S. L., Saykin, A. J., Considine, R. V., & Unverzagt, F. W. (2019). MIND food and speed of processing training in older adults with low education, the MINDSpeed Alzheimer’s disease prevention pilot trial. Contemporary Clinical Trials, 84, 105814. https://doi.org/10.1016/j.cct.2019.105814

Programa Nacional para Promoção de Alimentação Saudável. (n.d.). Retrieved May 12, 2022, from https://alimentacaosaudavel.dgs.pt/activeapp2020/wp-content/uploads/2019/12/Relato%CC%81rio_PNPAS_2019.pdf

De Seiça, M., Dias, R., Costa, D., & De Revisão, A. (n.d.). Mestrado Integrado em Medicina -Trabalho final : O impacto nutricional na doença de Alzheimer área científica de Nutrição. Trabalho realizado sob a orientação de: PROFESSORA DOUTORA LÈLITA SANTOS. Retrieved May 12, 2022, from https://estudogeral.sib.uc.pt/bitstream/10316/90048/1/Tese%20Final%20Mariana%20Costa.pdf

Cremonini, A. L., Caffa, I., Cea, M., Nencioni, A., Odetti, P., & Monacelli, F. (2019). Nutrients in the Prevention of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity, 2019, 1–20. https://doi.org/10.1155/2019/9874159

Féart, C. (2009). Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia. JAMA, 302(6), 638. https://doi.org/10.1001/jama.2009.1146

Dietas associadas à incidência reduzida da doença de Alzheimer Diets associated with the reduced incidence of alzheimer’s. (n.d.). Retrieved May 12, 2022, from https://repositorio.pucgoias.edu.br/jspui/bitstream/123456789/766/1/TCC%20Joabeth%20Rezende%20Ferreira.pdf

Hu, N., Yu, J.-T., Tan, L., Wang, Y.-L., Sun, L., & Tan, L. (2013). Nutrition and the Risk of Alzheimer’s Disease. BioMed Research International, 2013, 1–12. https://doi.org/10.1155/2013/524820

Kryscio, R. J., Abner, E. L., Caban-Holt, A., Lovell, M., Goodman, P., Darke, A. K., Yee, M., Crowley, J., & Schmitt, F. A. (2017). Association of Antioxidant Supplement Use and Dementia in the Prevention of Alzheimer’s Disease by Vitamin E and Selenium Trial (PREADViSE). JAMA Neurology, 74(5), 567. https://doi.org/10.1001/jamaneurol.2016.5778

Leal, T. (n.d.). UniAGES Centro Universitário Bacharelado em Nutrição Manejo Nutricional No Alzheimer: uma revisão integrativa Paripiranga 2021. Retrieved May 12, 2022, from https://repositorio.animaeducacao.com.br/bitstream/ANIMA/14369/1/Monografia%20Tawany-%20Corrigida%20e%20formatada.pdf

Machado, J., Caram, C. L. B., Frank, A. A., Soares, E. de A., & Laks, J. (2009). [Nutritional status in Alzheimer’s disease]. Revista Da Associacao Medica Brasileira (1992), 55(2), 188–191. https://doi.org/10.1590/s0104-42302009000200024

Morris, M. C., Tangney, C. C., Wang, Y., Sacks, F. M., Bennett, D. A., & Aggarwal, N. T. (2015). MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 11(9), 1007–1014. https://doi.org/10.1016/j.jalz.2014.11.009

Nooyens, A. C. J., Yildiz, B., Hendriks, L. G., Bas, S., van Boxtel, M. P. J., Picavet, H. S. J., Boer, J. M. A., & Verschuren, W. M. M. (2021). Adherence to dietary guidelines and cognitive decline from middle age: the Doetinchem Cohort Study. The American Journal of Clinical Nutrition, 114(3), 871–881. https://doi.org/10.1093/ajcn/nqab109.

Phillips, M. C. L., Deprez, L. M., Mortimer, G. M. N., Murtagh, D. K. J., McCoy, S., Mylchreest, R., Gilbertson, L. J., Clark, K. M., Simpson, P. V., McManus, E. J., Oh, J.-E., Yadavaraj, S., King, V. M., Pillai, A., Romero-Ferrando, B., Brinkhuis, M., Copeland, B. M., Samad, S., Liao, S., & Schepel, J. A. C. (2021). Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease. Alzheimer’s Research & Therapy, 13(1). https://doi.org/10.1186/s13195-021-00783-x.

Carvalho, A., Pinto, M., Renata, D., Oliveira, S., Coorientado, B., & Sampaio, D. (n.d.). Envelhecimento saudável: o papel da alimentação e nutrição Healthy aging: the role of diet and nutrition. Retrieved May 12, 2022, from https://repositorio-aberto.up.pt/bitstream/10216/133106/2/449401.pdf

Priulli, E., Pires, C. R. F., & Cezar, T. C. M. (2020). Alimentação como fator de proteção da doença de Alzheimer. Research, Society and Development, 9(10), e4259108895–e4259108895. https://doi.org/10.33448/rsd-v9i10.8895

De, L., & Ribeiro, S. (2017). Universidade Federal de Goiás Faculdade de Nutrição Alimentação Saudável e Cognição: um estudo da interface em idosos autônomos de Goiânia. https://repositorio.bc.ufg.br/bitstream/ri/12466/5/TCCG%20-%20Nutri%C3%A7%C3%A3o%20-%20Lorena%20de%20Sousa%20Ribeiro%20-%202017.pdf

Richard, E., Laughlin, G., Kritz-Silverstein, D., Reas, E., Barrett-Connor, E., & McEvoy, L. (2018). Dietary Patterns and Cognitive Function among Older Community-Dwelling Adults. Nutrients, 10(8), 1088. https://doi.org/10.3390/nu10081088

Román, G. C., Jackson, R. E., Gadhia, R., Román, A. N., & Reis, J. (2019). Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease. Revue Neurologique, 175(10), 724–741. https://doi.org/10.1016/j.neurol.2019.08.005

Rusek, M., Pluta, R., Ułamek-Kozioł, M., & Czuczwar, S. J. (2019). Ketogenic Diet in Alzheimer’s Disease. International Journal of Molecular Sciences, 20(16), 3892. https://doi.org/10.3390/ijms20163892

Faculdades ESEFAP -Tupã -São Paulo. (2011). http://www.cesumar.br/prppge/pesquisa/epcc2011/anais/edson_pilger_dias.pdf

Shishtar, E., Rogers, G. T., Blumberg, J. B., Au, R., & Jacques, P. F. (2020). Long-term dietary flavonoid intake and risk of Alzheimer disease and related dementias in the Framingham Offspring Cohort. The American Journal of Clinical Nutrition, 112(2), 343–353. https://doi.org/10.1093/ajcn/nqaa079

Da, E., Professora, S., Me, O., Maína, R., Pereira, C., & Brasília. (2018). EnsaioE CENTRO UNIVERSITÁRIO DE BRASÍLIA -UniCEUB FACULDADE DE CIÊNCIAS DA EDUCAÇÃO E SAÚDE CURSO DE NUTRIÇÃO ALIMENTAÇÃO COMO FATOR DE PROTEÇÃO PARA PACIENTES COM ALZHEIMER. https://repositorio.uniceub.br/jspui/bitstream/235/12643/1/21503459.pdf

Swaminathan, A., & Jicha, G. A. (2014). Nutrition and prevention of Alzheimerâ€TMs dementia. Frontiers in Aging Neuroscience, 6. https://doi.org/10.3389/fnagi.2014.00282

Tanaka, T., Talegawkar, S., Jin, Y., Colpo, M., Ferrucci, L., & Bandinelli, S. (2018). Adherence to a Mediterranean Diet Protects from Cognitive Decline in the Invecchiare in Chianti Study of Aging. Nutrients, 10(12), 2007. https://doi.org/10.3390/nu10122007

Taylor, M. K., Swerdlow, R. H., & Sullivan, D. K. (2019). Dietary Neuroketotherapeutics for Alzheimer’s Disease: An Evidence Update and the Potential Role for Diet Quality. Nutrients, 11(8), 1910. https://doi.org/10.3390/nu11081910

Thota, R. N., Rosato, J. I., Dias, C. B., Burrows, T. L., Martins, R. N., & Garg, M. L. (2020). Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer’s Disease. Nutrients, 12(4). https://doi.org/10.3390/nu12041032

Steffenon Weber, I. T., Conte, F. A., Busnello, M. B., & Bento Franz, L. B. (2019). NUTRIÇÃO E DOENÇA DE ALZHEIMER NO IDOSO: UMA REVISÃO. Estudos Interdisciplinares Sobre O Envelhecimento, 24(3). https://doi.org/10.22456/2316-2171.85168

Published

22/05/2022

How to Cite

Almeida , L. S., & Zupi , A. P. . (2022). Nutritional approach to Alzheimer´s disease: a literature review . E-Acadêmica, 3(2), e0632134. https://doi.org/10.52076/eacad-v3i2.134

Issue

Section

Health and Biological Sciences