Asherman’s Syndrome: Analysis of the effectiveness of stem cell-based therapy

Authors

DOI:

https://doi.org/10.52076/eacad-v3i1.108

Keywords:

Asherman's Syndrome; Stem cells; Endometrium.

Abstract

Asherman Syndrome (AS) is the partial or complete obliteration of the uterine cavity and/or cervical canal with uterine synechiae, resulting in amenorrhea, infertility and recurrent pregnancy loss, which varies with the severity of the lesions. Conventional treatment is hysteroscopy adhesiolysis, which aims to remove intrauterine adhesions and reconstruct the uterine cavity. One of the promising alternative treatments with a high success rate is based on the systemic or intrauterine inoculation of stem cells, which consists of regenerating endometrial tissue and reversing the damage. Thus, the aim of the following review is to analyze the effectiveness of stem cell-based therapy in Asherman Syndrome. This is a systematic literature review that used the PubMed, SciELO, Cochrane Library and LILACS platforms as databases for researching scientific articles, with a time frame between 2016 and 2022, in English. According to the search engine, 6 results were found after the exclusion criteria in PubMed, Cochrane Library and LILACS databases. Therefore, stem cell-based therapy was found to be effective in the treatment of AS, as endometrial stem cells derived from autologous adult stem cells have a high angiogenic potential and can regenerate a damaged endometrium, thickening the endometrium, returning to menstruation and increasing the rate of pregnancy and protected pregnancy. However, further studies should be carried out in order to ensure greater safety for patients, as there are side effects that can be harmful, such as endometriosis, endometrial hyperplasia and endometrial cancer.

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Published

03/04/2022

How to Cite

Fonseca, G. S. G. B. ., Coelho, M. B. C. ., Costa, A. V. B. de S. ., Fonsêca, J. S. G. B. ., Machado, P. S. ., Barros, B. M. E. B. L. S. ., Queiroga, A. V. R. ., Curvina, B. L. S. ., Britto, F. A. L. C. de ., Vieira, K. A. R. ., Guerra, V. S. ., Vasconcelos, A. C. S. L. ., Maluf, B. V. T. ., Ortegal, G. F. ., Prazeres, J. S. ., Lobato, L. da S. N. O. ., Pereira, N. S. R. ., Trindade, K. S. de M. ., Castro Filho, C. F. de ., Carvalho, C. M. de ., Britto, R. A. L. C. de ., Ferreira, J. P. ., Braga, M. C. C. ., Garcia, H. M. M. ., Nogueira, R. C. da R. ., Machado Castro Sousa, R. ., Nogueira, A. da R. ., Oliveira, V. M. A. de ., Dias, L. B. ., Florentino, J. V. P. ., & Soares, I. C. B. . (2022). Asherman’s Syndrome: Analysis of the effectiveness of stem cell-based therapy. E-Acadêmica, 3(1), e1731108. https://doi.org/10.52076/eacad-v3i1.108

Issue

Vol. 3 No. 1 (2022)

Section

Health and Biological Sciences

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Copyright (c) 2022 Gustavo Soares Gomes Barros Fonseca; Maria Beatriz Celedonio Coelho; Ana Valéria Brandão de Sá Costa; Júlia Soares Gomes Barros Fonsêca; Paula Soares Machado; Blenda Michelle Eloi Bezerra Lima Sousa Barros; André Vinícius Reis Queiroga; Bárbara Luysla Silva Curvina; Filipe Augusto Lopes Cajubá de Britto; Kivia Ariana Rodrigues Vieira; Vítor Saraiva Guerra; Ana Clara Sampaio Lima Vasconcelos; Bianca Vitória Teixeira Maluf; Guilherme Fialho Ortegal; Julianne Souza Prazeres; Luiza da Silva Nunes Oliveira Lobato; Narjara Sâmya Rodrigues Pereira; Karollyne Soares de Melo Trindade; Constantino Ferreira de Castro Filho; Camilla Menezes de Carvalho; Roberto Augusto Lopes Cajubá de Britto; Juliana Pessoa Ferreira; Maria Clara Chaves Braga; Hanna Michelle Melo Garcia; Rebeca Clery da Rocha Nogueira; Rebeca Machado Castro Sousa; Arthur da Rocha Nogueira; Virna Maria Araujo de Oliveira; Lorena Barros Dias; João Víctor Pacheco Florentino; Isabela Coelho Brito Soares

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